Karas(2005)

Karas is a Japanese anime series set in Shinjuku, where a rogue supernatural protector named Eko clashes with the city's mystical will for control. When the Karas sent to stop him falls, Shinjuku descends into danger. Otoha, a comatose hospital patient, awakens to discover she's been chosen as the new Karas—a guardian spirit bound to defend the city. Now she must confront Eko in a high-stakes battle that will determine Shinjuku's future. The series blends urban fantasy with intense action as Otoha grapples with her newfound powers and the weight of protecting millions of lives.