Z.O.E Dolores, i(2001)

Z.O.E Dolores, i is an anime series following James Lynx, a former UN pilot who abandoned his military career after his wife, a Martian scientist, died in a lab accident. Wracked with guilt and estranged from his children, James takes work as a transporter between Earth and Mars, clinging to a faint hope she might still be alive. Years of disappointment drive him to drink. Everything changes when he receives an orbital frame—a powerful combat machine called Dolores—mysteriously sent by his deceased wife. The gift reignites James's purpose and sets him on an unexpected journey that blurs the line between loss and redemption.